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Prof Nicolas Van Mieghem and Dr Joost Daemen return with their critical review series, View from the Thoraxcenter, to preview the most anticipated late-breaking and featured science trials of ACC.23.

Which trials have the potential to change practice? What are the key considerations for patient care and research? What is the context of the top trials of ACC?

Trials covered in detail include:

Structural Intervention
0:25: TRILUMINATE Pivotal: A Landmark Randomized Clinical Trial of Transcatheter Tricuspid Valve Edge-to-Edge Repair for Tricuspid Regurgitation
3:19: UK Mini Mitral: Minimally Invasive Versus Conventional Sternotomy for Mitral Valve Repair Surgery: An Expertise Based Multicentre Randomised Controlled Trial
5:08: COAPT: Transcatheter Edge-to-edge Repair of Functional Mitral Regurgitation in Heart Failure: Final Five-year Results
7:23: Evolut Low Risk: Transcatheter Versus Surgical Aortic Valve Replacement in Aortic Stenosis Patients at Low Surgical Risk: 3-year Outcomes

Coronary Intervention
9:22: REVIVED-BCIS2: Effect of Myocardial Viability, Percutaneous Coronary Intervention and Functional Recovery on Clinical Outcomes
11:28: RENOVATE-COMPLEX-PCI: Intravascular Imaging-guided Versus Angiography-guided Procedural Optimization in Complex Percutaneous Coronary Intervention
14:19: BIOVASC: Complete Revascularization Strategies in Patients Presenting with Acute Coronary Syndromes and Multivessel Coronary Disease

Statins
15:55: Yellow III: Effect Of Evolocumab On Coronary Plaque Characteristics in Stable Coronary Artery Disease: A Multimodality Imaging Study
18:03: CLEAR Outcomes: Bempedoic Acid and Cardiovascular Outcomes in Statin Intolerant Patients At High Cardiovascular Risk
20:41: MK-0616: Efficacy And Safety of The Oral PCSK9 Inhibitor, MK-0616, A Macrocyclic Peptide, in the Treatment Of Hypercholesterolemia: A Phase 2b Randomized Placebo-Controlled Clinical Trial

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