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Grey's Anatomy is an American medical drama television series focusing on the personal and professional lives of surgical interns, residents, and attendings at the fictional Seattle Grace Hospital, later named the Grey Sloan Memorial Hospital. The series premiered on March 27, 2005, on ABC as a mid-season replacement. The show's title is a reference to Gray's Anatomy, a classic human anatomy textbook. Writer Shonda Rhimes developed the pilot and served as showrunner, head writer, and executive producer until stepping down in 2015.

Plot
The series follows the life of Meredith Grey (Ellen Pompeo), the daughter of world renowned general surgeon Ellis Grey (Kate Burton), starting from her acceptance into the surgical residency program at the fictional Seattle Grace Hospital (later named Seattle Grace Mercy West, and finally, Grey Sloan Memorial Hospital). During her time as an intern, Grey works alongside fellow physicians Cristina Yang (Sandra Oh), Izzie Stevens (Katherine Heigl), Alex Karev (Justin Chambers) and George O'Malley (T. R. Knight), who each struggle to balance their personal lives with hectic schedules and stressful residency requirements. During their internship, they are overseen by Miranda Bailey (Chandra Wilson), a senior resident, who works with attending physicians Derek Shepherd (Patrick Dempsey), head of neurosurgery and Meredith's love interest, and Preston Burke (Isaiah Washington), head of cardiothoracic surgery and Yang's eventual fiancé. Richard Webber (James Pickens Jr.), Chief of Surgery and attending general surgeon, is the former lover of Ellis Grey. During the first six seasons, Burke, O'Malley, and Stevens all depart the series.