The Breakfast Club initially was broadcast from the NBC studios in the Merchandise Mart. In 1948, after 4,500 broadcasts from the Merchandise Mart, the program moved to the new ABC Civic Studio. It was also heard from other Chicago venues: the Terrace Casino (at the Morrison Hotel), the College Inn Porterhouse (at the Sherman House) and "the Tiptop Room of the Warwick Allerton Hotel on Chicago's Magnificent Mile," as well as tour broadcasts from other locations in the U.S.
It remained a fixture on the ABC radio network (formerly the NBC Blue Network; it became known as ABC in 1945), maintaining its popularity for years and counting among its fans Supreme Court Associate Justice William O. Douglas.
After ABC Radio was split into four networks in 1968, The Breakfast Club was moved to the new American Entertainment network, and was known for its last months on the air as The Don McNeill Show.