
Jackie Peyton (Edie Falco) is an emergency department nurse at the fictional All Saints Hospital in New York City. She has two daughters and is married to her husband Kevin (Dominic Fumusa), although she is having an affair with the hospital pharmacist Eddie (Paul Schulze) in exchange for pills. Her allies at the hospital include Dr. Eleanor O'Hara (Eve Best), new nurse Zoey Barkow (Merritt Wever), and hard-lined administrator Gloria Akalitus (Anna Deavere Smith). Over the course of the first season, she spars with Dr. Fitch Cooper (Peter Facinelli), whom Jackie finds obnoxious, and tries to help her anxious daughter Grace (Ruby Jerins). Other All Saints staff members include Momo (Haaz Sleiman), Thor (Stephen Wallem), Sam (Arjun Gupta), Dr. Ike Prentiss (Morris Chestnut), Dr. Carrie Roman (Betty Gilpin), and Dr. Bernard Prince (Tony Shalhoub).