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Bruce Banner endures a life without a past, yet filled with dreams. As a genetic scientist, Bruce studies the effects of gamma radiation on damaged tissue. Unaware that there is a monster inside him, Bruce continually struggles with fits of anxiety, embarrassment and rage. One day during a freak lab accident, Bruce's inner beast is unleashed and he becomes the most powerful being on the face of the earth - the Hulk.
As the son of a real-life mad scientist, Bruce has a less than idyllic childhood. Bruce's father, David Banner, is a genetics researcher who experiments on himself, trying to improve human DNA. Once David's wife gives birth to their son Bruce, David realizes his mutant DNA has been passed on and attempts to find a cure for his son's condition. But the government, represented by Thaddeus "Thunderbolt" Ross, shuts down David's research after learning of his dangerous experiment. In a fit of rage, David causes a massive explosion of the facility's gamma reactor and accidentally kills his wife.
After David Banner's institutionalization, 4-year-old Bruce is sent into foster care and adopted, taking on the last name Krenzler and believing that both of his biological parents are dead. Young Bruce is a withdrawn and closed child, rarely outwardly expressing emotion, even in extreme cases, with patches of green skin that appear when he feels intense emotions. Throughout his life, the repressed memories of his parents, the explosion, and his early childhood manifest as intense nightmares that leave Bruce shaken and disturbed but unable to conjure the memories.
Years later, Bruce is a brilliant researcher, freshly graduated and working at the bionuclear research facility of the University of California, Berkeley. His ex-girlfriend and equally brilliant fellow researcher, Betty Ross, has tired of Bruce's cordoned-off emotional terrain and resigns herself to remaining an interested onlooker to his quiet life. They use nanomeds activated by gamma radiation from a device called a Gammasphere (but operates differently from a genuine Gammasphere) to regenerate living tissue; the nanobot experiments result in out-of-control cellular growth and are invariably fatal to the amphibian test subjects. David Banner reappears and begins infiltrating his son's life, working as a janitor in the lab building. The military-industrial complex, represented by the depraved Major Talbot, becomes interested in the research to build self-healing soldiers. "Thunderbolt" Ross—now an Army General and Betty Ross's estranged father—also starts investigating when he learns through Talbot of Bruce's involvement in the research. Ross becomes concerned for his daughter's safety around Banner, partly because Bruce works in the same field as his father did. As Bruce, Betty, and their colleague Harper, continue to make progress in their experiments, they experience an accident during a typical power-up when there is an overload of the nanobots with Harper stuck in the lab testing room. Bruce saves Harper and takes the brunt of the gamma radiation himself. Later, as Bruce sits in a hospital bed, he tells Betty that he's never felt better, which she can't fathom since the nanomeds have killed everything else they've touched. Unknown to them, the radiation has intertwined with Bruce's already-altered DNA.
That same night, his father confronts him, revealing their relationship and hinting at the mutation in his son. Using Bruce's DNA, he begins experimentation on animals. Soon after, the building rage within Bruce stemming from the stresses building up around him (his father, Betty, Talbot, and the accident) activates his gamma-radiated DNA, triggering Bruce's signature transformation into the Hulk. His father sees him in his transformed state and is in awe and horror of what he has created, deepening his obsession.