Genís Ona - Preliminary efficacy and safety of ibogaine for the treatment of methadone dependence

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Preliminary efficacy and safety of ibogaine for the treatment of methadone dependence.

ABSTRACT
Methadone is commonly used for the treatment of opioid dependence, but its long-term use can lead to adverse effects and dependence. Ibogaine has been suggested to be effective in treating opioid dependence. However, no controlled studies have been published with this substance and there is only one Phase-I trial informing about the pharmacokinetics of a dose of 20 mg of ibogaine. In 2020, ICEERS started the recruitment for a randomised and double-blind trial aiming to investigate the safety and efficacy of repeated, low doses of ibogaine in the treatment of methadone dependence. In this presentation, the data on first administrations (100 mg ibogaine) of 14 participants will be presented.

BIOGRAPHY
Genís Ona is a psychologist and specialist in Pharmacology research. Associate Professor at the Universitat Rovira i Virgili (URV) of Tarragona, Spain, he performed professional stays at the Institut Botànic de Barcelona (IBB-CSIC), Spain, and at the University of São Paulo, Department of Neurosciences and Behavior, Brazil. He is member of the working group about psychedelics of the Societat Catalana de Psiquiatria i Salut Mental. He is also a PhD candidate in Health, Psychology and Psychiatry.

He is currently developing scientific research at ICEERS, in the Medical Anthropology Research Center (URV), and at the Sociedad Española de Medicina Psicodélica (SemPSI).