Gastroesophageal reflux disease (GERD) is a digestive disorder that develops from continuous exposure of the esophagus to acidic reflux from the stomach. Raft-forming anti-reflux preparation is one line of treatment where a viscous gel forms a physical barrier above the stomach contents and prevents it from refluxing back into the esophagus. Sodium alginate is one of the key ingredients in such formulations. The aim of this presentation is to highlight the effect of various formulation components on the raft properties. Additionally, a novel method for raft testing will be introduced, which will help to provide a deeper understanding about the resistance of the gels against applied forces under in-vitro conditions. We will then correlate this raft strength data and the testing to understand the behavior in in-vivo conditions in the human stomach.
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