How the brain works has always been a particular source of wonder to me. I was fascinated in how the dynamics of literal brain chemistry can change the entire computational process. Recently I have been wondering more and more about what exactly "being high" means. What is happening on a biomolecular level when we ingest cannabis? What changes in neurons that causes things to be perceived so differently?
This video wound up requiring the most reading I've ever done on a topic. The exact biomolecular mechanisms are nuanced and still not completely fleshed out. Especially with regards to processes beyond the dopaminergic pathways.
But this should be a pretty comprehensive overview of getting you up to speed on what's happening.
Used Sources:
The endocannabinoid system -
Review of the Endocannabinoid System -
An Introduction to the Endogenous Cannabinoid System -
Sustained Elevation of Dendritic Calcium Evokes Widespread Endocannabinoid Release and Suppression of Synapses onto Cerebellar Purkinje Cells -
Adenylyl Cyclase -
NEUROTRANSMITTER IDENTIFICATION AND ACTION: IONOTROPIC RECEPTORS VERSUS METABOTROPIC RECEPTORS -
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review -
Endocannabinoid modulation of dopamine neurotransmission -
CB1 Cannabinoid Receptors and their Associated Proteins -
Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits -
VTA GABA Neurons at the Interface of Stress and Reward -
Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice -
Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice -
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