City saw a two-goal lead wiped out by a resurgent Brighton who recovered to win 3-2.
Joao Cancelo was red carded after just 10 minutes, but goals from Ilkay Gundogan and Phil Foden looked to have put City on the way to a 13th Premier League away win in succession.
But the Seagulls, buoyed by a passionate home crowd, eventually made the extra man pay with three second-half goals to secure a first top flight victory over City for 40 years.
Match report can be read here:
SUBSCRIBE!
About the Official Man City YouTube Channel:
Here you will find all the latest videos from Manchester City, including, all Premier League goals, highlights, behind-the-scenes footage, training and much more.
Get closer to the likes of Sergio Aguero, Kevin De Bruyne, Gabriel Jesus, Raheem Sterling, Riyad Mahrez, Benjamin Mendy and the rest of Pep Guardiola's team.