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We are joined onsite by Dr John Forrest (Yale Valve Clinic, US) in this short video, who outlines the three-year outcomes of the Evolut Low-Risk Trial (Medtronic Cardiovascular). This study aimed to compare transcatheter aortic valve replacement (TAVR) using Medtronic's TAVR valve with surgical aortic valve replacement (SAVR) in over 2000 patients with aortic stenosis who had low surgical risk.

TAVR had consistent benefit at 3 years compared with surgery in terms of all-cause mortality and disabling stroke.

Questions:
-What is the reasoning behind this trial?
-Please outline the patient population and study design.
-What are the main results?
-What are the implications of these findings for clinical practice?
-What further research is required?

For more content from ACC.23/WCC and the Late-breaker Discussion series head to Late-Breaking Science Video Collection.

Recorded on-site at ACC.23, New Orleans, 2023.
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