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Insulin and Glucagon | Physiology | Biology | FuseSchool

In this lesson, you will learn about how your blood glucose level is regulated (or controlled) by two important hormones – insulin and glucagon, via a negative feedback system.

When you consume a meal that is high in carbohydrates, such as rice, pasta, and bread, this will cause your blood glucose level to increase. Carbohydrates are essentially long chains of repeating glucose monomer units, much like beads on a necklace.

During digestion, this is broken apart into glucose, which absorbed into our bloodstream. This increased blood glucose level causes a gland known as the pancreas to secrete a hormone called insulin. Remember that a gland secretes hormones which act on specific target organs.

In this case, the target organ is your liver, which is stimulated to convert glucose to glycogen.
Glycogen is basically long, multi-branched chains of glucose monomers, stored in liver and muscle cells. Insulin also causes your body cells to uptake (or take in) glucose. So this decreases your blood glucose level back to its optimal state.

When this system is faulty, this leads to a medical condition known as diabetes – if you want to learn more about diabetes, this will be addressed in another video. The same response also occurs when you consume foods and drinks high in sugar such as sweets, cakes, and fizzy drinks.

When your blood glucose level drops, such as when you are hungry, the pancreas secretes a hormone called glucagon. Like insulin, the target organ for glucagon is also the liver, though it stimulates the opposite process – the breakdown of glycogen into glucose. This increases your blood glucose level back to its optimal state.

To review, insulin and glucagon are two hormones released by the pancreas, which act on the liver to regulate our blood glucose level.



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